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HABITAT cell
HABITAT cell
The HABITAT cell control tower package is particularly suitable for HABITAT’s cell culture applications and is used to monitor and control the bioprocess. It includes the control unit with all connection options for gas supply, liquid addition, sensors and temperature control as well as a tablet for easy and clear operation of the bioreactor.
Control and monitoring
The bioprocess and all associated test parameters can be easily controlled and monitored via the tablet attached to the control unit and with the help of the intuitive and easy-to-use software. Depending on the type of cultivation, you can choose between the operating modes batch, fed-batch and perfusion/continuous. The new Chaotic Mixing function ensures faster and more effective mixing when required. The 10.4-inch tablet allows direct access to all actuators directly on the main screen. A clear calibration management, a diagram overview and the complete documentation of the process round off the operation. A software version that meets FDA CFR Part 11 requirements is available as an option.
Gas supply
Built in mass flow controllers for 4 separate gas lines (for N2, O2, air and CO2) ensure precise, individually adjustable gassing, ideally tailored to the needs of your cells. Flow rates of 0.01 - 2 l/min can be achieved.
Liquid supply
4 integrated Watson Marlow pumps, adjustable in direction and speed, give you the variability to pump in and pump out different liquids (like acid, base, anti-foam agent, feeding solutions).
Sensors
HABITAT cell enables the measurement of the following parameters by means of sensors:
• pH
• DO (dissolved oxygen)
• temperature
• filling level
• foam
Temperature control
The constant and precise temperature control during the cultivation is guaranteed by the heating sleeve, which is adapted to the respective vessel size. (Heating sleeve is included with the HABITAT cell vessel package).
All features at a glance
> compact, space-saving design, dimensions: 223 x 402 x 450 mm (WxDxH)
> large tablet for clear operation (10,4 inch)
> intuitive, easy-to-use software with a lot of functionalities.
> 4 integrated fast-load pumps (Watson Marlow)
> connectivity: USB, PC, RS232, ethernet, external signal input, external pump, single-use unit, thermostat
> data storage
> gas supply with 4 built-in mass flow controllers: e.g. for O2, Luft, N2, CO2
> Status LED display: direct error display by indicator light
Note: Only a control tower package and the separately available vessel package make up a functional unit.
Scope of delivery
HABITAT cell S099
Tablet with software for bioreactor
HA.pl. Peltier cooling element
Technical Data
| Controller | Cell Growth |
| Operating mode | timer, continuous and program operation |
| Display | Tablet PC |
| Operation | touch screen |
| Data memory size | 32 GB |
| Auto restart after power failure | yes |
| Ethernet interface | yes |
| Single use reactor interface | yes |
| Thermostat interface | yes |
| Ext. pump interface | yes |
| Gravimetric feeding | yes |
| Exponential feeding | yes |
| Biomass feeding | yes, with CGQ BioR Sensor |
| OPC UA interface | yes |
| Filter heater | yes |
| LED light panel | Accessory |
| Stirring motor | yes |
| Calibration guide temperature | yes |
| Calibration guide pH | yes |
| Calibration guide pO2 | yes |
| pH - temperature compensation | yes |
| Mode hose filling | yes |
| Stirrer control mode | off, manual, profile, Cascade-pO2 control, chaotic |
| Speed range | 1 - 2200 rpm |
| Speed deviation >= 100 rpm | ±2 % |
| Speed deviation <= 100 rpm | ±5 rpm |
| Speed display | TFT |
| Reversible direction of rotation | yes |
| Timer | yes |
| Timer display | TFT |
| Time setting range | 1 - 120 min |
| Heating blanket | yes |
| Heat output | 250 W |
| Heat control | TFT |
| Temperature control | PID |
| Working temperature | 5 - 80 °C |
| Connection for ext. temperature sensor | PT1000 |
| Temperature display | yes |
| Temperature measuring range | 0 - 100 °C |
| Temperature measurement resolution | 0.1 K |
| Temperature control accuracy | ±0.2 °C |
| Temperature limit min. | 0 °C |
| Temperature limit max. | 110 °C |
| pH measurement | yes |
| pH control mode | off, auto, profile |
| pH value display | TFT |
| pH measuring range | 0 - 14 pH |
| pH measurement resolution | 0.01 pH |
| Accuracy of pH measurement | ±0.02 pH |
| Set resolution pH value | 0.01 pH |
| pH control accuracy | ±0.05 pH |
| Conncetion for pO2 sensor | yes |
| pO2 control mode | off, manual, auto, profile |
| Measurement range pO2 min. | 0 %sat |
| Measurement range pO2 max. | 200 %sat |
| Resolution pO2 measurement | 0.01 %sat |
| Accuracy of pO2 measurement | ±0.3 %sat |
| pO2 control accuracy | 0.3 %sat |
| Exhaust Gas Analyzer | yes, with Blue Vary Sensor |
| OUR,CER,RQ calculation | yes, with Blue Vary Sensor |
| RQ feeding | yes, with Blue Vary Sensor |
| Digital pH sensor | yes, with EasyFerm Bio Arc Sensor |
| Measuring Range min. digital pH | 0 pH |
| Measuring Range max. digital pH | 14 pH |
| Accuracy digital pH | ±0.02 pH |
| Digital DO sensor | yes, with OxyFerm FDA Arc |
| Measuring Range min. digital DO | 0 %sat |
| Measuring Range max. digital DO | 200 %sat |
| Accuracy digital DO | ±2 % |
| Optical DO sensor | yes, with VisiFerm RS485-ECS |
| Measuring Range min. optical DO | 0 %sat |
| Measuring Range max. optical DO | 300 %sat |
| Accuracy optical DO | ±1 % |
| Biomass sensor | yes, with CGQ BioR Sensor |
| Measuring Range min. Biomass | 0.5 OD |
| Measuring Range max. Biomass | 50 OD |
| Digital Redox / ORP sensor | yes, with EasyFerm Plus ORP Arc |
| Measuring Range min. digital ORP | -1500 mV |
| Measuring Range max. digital ORP | 1500 mV |
| Digital biomass sensor | yes, with Excell Sensor |
| Measuring Range min. digital biomass | 0 AU |
| Measuring Range max. digital biomass | 6 AU |
| Accuracy digital biomass | ±1 % |
| Viable Cell Density Sensors | yes, with Incyte Sensor |
| Measuring Range min. cell density | 5 x 10^5 cells/mL |
| Measuring Range max. cell density | 8 x 10^9 cells/mL |
| Accuracy cell density | ±1 % |
| Gas in connection Air | 6 mm |
| Gas out connection Air | 6 mm |
| Gas in connection O2 | 6 mm |
| Gas out connection O2 | 6 mm |
| Gas in connection N2 | 6 mm |
| Gas out connection N2 | 6 mm |
| Gas in connection CO2 | 6 mm |
| Gas out connection CO2 | 6 mm |
| Aeration mode | continuous & automatic |
| Display flowrate | l/min, cc/min |
| Input pressure | 200 - 3000 mbar |
| Pressure out min. | 200 mbar |
| Pressure out max. | 1000 mbar |
| Flowrate Air min. | 1 cc/min |
| Flowrate Air max. | 2000 cc/min |
| Flowrate O2 min. | 1 cc/min |
| Flowrate O2 max. | 2000 cc/min |
| Flowrate N2 min. | 1 cc/min |
| Flowrate N2 max. | 2000 cc/min |
| Flowrate CO2 min. | 1 cc/min |
| Flowrate CO2 min. | 2000 cc/min |
| Measuring and control accuracy of the gas control units | ±2 % fsr |
| Peristaltic pump | yes |
| Numbers of pump heads | 4 |
| Pump head function | Acid, Base, AntiFoam, Level |
| Pump head | Watson Marlow 114DV |
| Number of pump tubes | 4 |
| Number of pump rollers | 4 |
| Flow rate min. | 0.3 ml/min |
| Flow rate max. | 270 ml/min |
| Flow rate control accuracy | ±0.3 ml/min |
| Pump Speed min. | 33 rpm |
| Pump Speed max. | 400 rpm |
| Pump reversible direction of rotation | yes |
| Pump speed display | TFT |
| Inner tube diameter min. | 0.5 mm |
| Inner tube diameter max. | 4.8 mm |
| Tube outer diamter min. | 4.1 mm |
| Tube outer diamter max. | 8.4 mm |
| Tube material | Silicone |
| Tube hardness | 50 - 60 Shore A |
| Dimensions (W x H x D) | 224 x 624 x 405 mm |
| Weight | 14 kg |
| Packing unit | 1 pcs |
| Permissible ambient temperature | 5 - 40 °C |
| Permissible relative humidity | 80% (up to 31°C), decreasing linearly to max. 50 (@40°C) |
| Protection class according to DIN EN 60529 | IP 20 |
| RS 232 interface | yes |
| USB interface | yes |
| WiFi Interface | yes |
| Voltage | 100 - 240 V |
| Frequency | 50/60 Hz |
| Power input | 300 W |
| Power input max. | 1100 W |
| Power input standby | 10 W |
| Fuse | 2x T5.0A 250V |